Used as an extreme of the word "Fuck". You would use it in any situation where you would use the word "Fuck". Or just simply insert it into any sentence replacing the noun, adjective, or verb. Makes 'em know you ain't megafucking kidding.
Adjective:

That guy's a megafucking loser!
Noun:

That party was such a megafuck!
Verb:

Dude, I totally megafucked Jessica last night!

I megafucking hate getting a dirty sanchez!
Get the Megafuck mug.
when megavideo's 72 minute time limit stops you from watching your favorite tv show
I was in the middle of this sex scene in Entourage where Sloan gets naked and I got megafucked.
by stick up my ass August 31, 2009
Get the megafucked mug.
Gender-neutral variant on expletive motherfucker. Anyone who's just really, a real fucker, you know?
Cinematic event of the day: This megafucker in the Benz tried to run me off the road, so at the next stop light I bashed in his window with my U-Lock and took off.
by eyeyey March 16, 2005
Get the megafucker mug.
1.to fuck with excessive force
Mike megafucked the blow-up doll and made it explode.
2. a unit of measuring fucks
1024 fucks equals a kilofuck, 1024 kilofucks equals a megafuck
1. Mike megafucked the blow-up doll and made it explode.

2.1024 fucks equals a kilofuck, 1024 kilofucks equals a megafuck
by Ph@7e December 14, 2004
Get the megafuck mug.