To feel good no matter what kind of drug you are on. usually prescription drugs.
Ahhhhhh! man i feel nice and medicated.
To be high on marijuana. Marijuana helps glaucoma, and chemotherapy so it's a medicine. It's just a more proper way of saying high.
jose- "Damnnnnnnnnnnnn, he is high!"
pete & patrick "Nah man, He's just medicated"