Top Definition
Feeling sick and depressed after eating medium to large amounts of McDonalds. It doesn't happen every time, but it is a common occurrence. Eating McDonalds several times in a row can increase chances of the McBlues.
- "After our football game, I ate like 2 big macs and got the worst McBlues ever."

- "Everyone had the McBlues after eating McDonalds 3 days in a row on our road trip."
by TheChronicKingWes115 November 08, 2009
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