Top definition
The act of executing every bodily function all at once. Crying, puking, sneezing, bleeding, sweating, defacating, urinating etc. (use your imagination) normally brought on by extreme stress.
she was so hot she made me mastigulate.

As he entered the witness stand he began to mastigulate.

Mastigulation is common at Guantanamo Bay.
by Remo "Uzi" Gwaldabi March 22, 2011
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