Top Definition
Often spoken with a spanish accent:

1. To cause something to be insane, metaphorically.
2. An expression of good will.
3. A general exclaimation.
1. Will: I'm goin' to the thrift store.
Jason: Make it loco, man!

2. Jason: Sorry I can't go man. I have a date tonight.
Will: Oh, nice.. make it loco dude.

by J_a_s_o_n October 02, 2006
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