Luke Disease is belittlement of the penis, erectile dysfunction, gayness and general rtardness. There is no known cure for this, sufferers are too rtarded and gay to accept a cure.
Known sufferers: Luke
Jole: "OMG, That My Rtarded friend was acting all gay today, and in the changing room, I saw his cock, it was the size of a PEA. He told me he had erectile dysfunction O_O"

DAVID: "OMFGZ, HE HAZ LUKE DISEASE!"
by Daemonius :] July 25, 2008
Get the Luke Disease mug.
the coolest disease to have. if you have it your awesome and every one wants it
"hes so cool" "yeah he has Luke disease"
by lukes bff May 16, 2018
Get the Luke Disease mug.
A fear of the dark side of the force; or a white girl that is afraid to go out with a black guy.
Nah, man, that girl would never go black, she's got a serious case of Luke Skywalker Disease.
by EarthMaiden April 3, 2012
Get the Luke Skywalker Disease mug.