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2.
when you are jacking off and someone pulls into the driveway right as you are blowing a load
"dude i had to make a jizz run when my girlfriend pulled up last night!!"

"dude me to!!!"

by mr_kirch February 28, 2008
 
1.
After the physical act of copulation, if the male ejaculate is allowed to spill inside the female cervix, she will most likely run or walk (at a brisk pace) to the lavatory to allow said ejaculate to drain from her nethers.
Last night my missus went for a Jizzrun but didn't make it, so I made her clean the floor...

With her undies.
by Thunderbox69 August 04, 2013