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1.
The severe backup of semen, cum, load, in an ear. Usually caused by a 41 or 82.
Jordan Boehler got fucked in the ear so hard last night he was diagnosed with a severe and possibly fatal case of jizzbrain.
by Henry Finkler April 26, 2004
 
2.
when gay men shove dicks in each others ear so much that jizz comes in contact with the brain
mike has jizzbrain
by stinky May 27, 2003
 
3.
verb. When you're deep throating a betch and you dick goes up instead of down and you ejaculate all up in there brain
Oooh I was with James last night and i totally jizz-brained his betch ass.
by Matthew The Pimp Fucker May 31, 2007