A drug Neapolitan
Lame Fat Dude: Uh, guys? What is this stuff? My heart's going really fast.

Cool British Dude: Oh, it's a bit of this, a bit of that. It's called a Jeffrey. It's mostly weed, with a bit of opium as well... ground-up E's... heroin... Clorox...
by Raeper142 October 15, 2010
A joint containing a mixture of marijauna and drugs. These can include-but are not limited to-angeldust, coicaine, heroin, methadone, methamphetamines, etc. So named because "nobody's scared of a Jeffrey" (to paraphrase Aldous Snow, lead singer of Infant Sorrow in "Get Him To The Greek")
Wanna hit off this "Jeffrey?"

Naw man, I stick with the sticky-icky.
by LegalizeMedicine420 June 04, 2010
The act of slapping another individual's face with one's dick after being vomited on or pooped on while receiving a blow job or performing anal sex with that individual as a form of punishment.
That girl shat all over my dick so I gave her the Jeffrey.

While she was deep-throating me, she vomited on my dick, so I gave her the Jeffrey.
by dawgystylez90210 September 06, 2011
This term was used in the movie "Get Him To The Greek". It is a concoction of mostly marijuana laced with opium, heroin, peyote, methadone, crushed up ecstasy, some of it is unidentifiable, and hint of angle dust and possibly a few other things.

I'm pretty sure this was actually cleverly named for Jeffrey Miron, a Harvard economist who is lobbying for the legalization of ALL drugs.
"Nobody's scared of a jeffrey." "Jeffrey's just a bloke down the street." ~ Get Him To The Greek

From the sounds of what all is in it, I think it would be really stupid to smoke a jeffrey. You'd probably die instantly.
by Shadowbane1 November 09, 2010
A joint(cigarette) rolled with weed, opium, herion, crushed up ecstasy, clorox, morphine, a little bit of angle dust, and some unidentifiable ingredients
Guy 1: I'm tripping out on this jeffrey, man.
Guy 2: It's okay, just stroke the furry wall.
by Aldous Snow June 14, 2010
From the 2010 movie "Get Him To The Greek" it is a smokable joint consisting of:
- Weed mostly
- A bit of Opium
- Heroin
- Crunched up Ecstacy
- Clorox
- Methadone
- Subutex
- Morphine
- Peyote
- Some of the stuff is unidentifiable
- A little bit of Angel Dust
"You're freakin' out man chill, here take a hit of this Jeffrey!"
by TexIVXX November 19, 2010
A blunt with a huge amount of drugs in them (crack cocaine,Heroin ,Ecstasy,etc.
Jessica was smoking a Jeffrey at the party last night
by BIGGPImpinnn July 12, 2011

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