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When you're in very serious trouble. More trouble than when someone says that they're "in the shit". A clean version of this is "In the DS".
Example #1: Fuck! We're in the damn shit for about $80,000 bucks!

Example #2: Fuuka just found out her boyfriend totally cheated on her with Yukari. Oooh, he's in the damn shit now...
by MasterMenos August 12, 2012