Murder verbally or physically. Used by 2-pac or Lil Weezy(Lil`Wayne). A killing. Used to threaten a group of people.
Nigga I HIT-EM-UP. He hit-em-up. Imma hit-em-up
by MAC L. May 16, 2007
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Get on the road do some soul searching after getting high!
Sometimes I just like to Hit Em Up and hit the highway!
by USer 55 November 20, 2006
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Soft and offensive. Just like you.

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Some gay ballerina kid getting out of jail and rappin about a fat man.
Have you heard Hit Em' Up?

Yeah its shit!
by Raizoladdd May 31, 2015
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The vengeful act of crapping on a lover's chest while they sleep.

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