Top Definition
The act of making a wheezing noise while laughing.
"OMG! what you just said, made me laugh so hard i started HISSSing! HISSSSSSSS!"
by Rachael and Nicole. July 27, 2008
Jimmy: (nervously) Hi, little snake...
Snake: HISSS!

Yvette: OK, Spot, you can pee now.
Spot: Ruff, ruff!

by TopherGopher April 01, 2013

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