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Also used to refer to people, with the same connotation as other slang terms for vagina. Intended to insult the person's bravery or manhood. Still spelled with an enyeah.
"Did Tom go on the ride with the rest of them?"

"No, he was a total Guana."
by racingrickster April 21, 2006
A slang term for the vagina. Usually used to refer to particularly unappealing vaginas. Is spelled with a accent called an "enyeah"
I saw Oprah getting out of a limo yesterday, and when she stuck her leg out, I totally saw Oprah's guana.
by racingrickster April 21, 2006