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22.
1. mildly ludicrous, laughable, sometimes dearly, inoffensive stupid person or an act

2. a kind of sleeping pill or drug that is sedative, hypnotic, and antispasmodic and is often addictive. Examples include crystal meth, coke, heroine, LSD, magic mushroom.
A: Why is Katy wearing her panties as tiara?
B: She's such a goofball.
A. The goofball could be on goofball.
by SGreen October 07, 2009
 
1.
A total idiot, someone who lacks any intelligence at all.
my little brother is such a goofball
by knobgoblin August 28, 2009
 
2.
Slang term for Barbiturates.
Barbiturates, such as phenobarbital and secobarbital, are any of various derivatives of barbituric acid used especially as sedatives, hypnotics, and antispasmodics.
Barbiturates have largely been supplanted by Benzodiazepines (such as Valium, Xanax) due to addictive potential, extensive abuse, and severe withdrawal syndromes.
I need to hook up some goof balls, to help me kick heroin
by narkologik May 21, 2005
 
3.
Someone who is silly or stupid. Also looks silly or stupid.

Opposite of a chill bro.

People generally laugh at them than with them.
A: Do you know Declan?
B: Nah, I don't.
A: You know, the massive goofball?
B: Oh, yep! He's the king of goofballs.
by Double Denim Ranga August 02, 2010
 
4.
slang term for methamphetamine and other oral forms of various illegal drugs
that guy Overdosed on goofballs, now he is in a coma.
by grizzlymaster March 06, 2009
 
5.
A term of endearment between online friends, similar to "buddy", "bro", etc. Tends to be used when one friend does something silly or funny.
Used mainly in America by those unfamiliar with the derogative form of the word.

Also used: goof, goofball, goofy
"You're such a goofball :P"
"You're so goofy"
by BohemianGoof February 10, 2012
 
6.
What practicing scientologists ingest. Usually in great overwhelming amounts.
In our service today, we will include the sacred goof balls.
by Dianetic_chancellor September 13, 2006
 
7.
A term for barbituates mostly used in the early part of the 20th century.
William Burroughs did a lot of goof balls.
by Arvin Smee January 25, 2006