To be provoked by someone/something to such a point that a verbal reaction becomes inevitable.
Why's that kid shitting on Tom's car? Tom's gonna go off on one in a minute.
by Manson April 27, 2005
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if you are bisexual, going from dating a guy to dating a girl
Man: Hey did you hear Tammy broke up with Max and got together with Edie?

Man 2: Yeah, she’s going off the stick.
by swish the bish March 30, 2020
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The true key to our 45th US President’s wide appeal and ongoing superhero status with his “base.”
Going off script, he said, “when the wind stops blowing, that’s the end of your electric...darling...darling, is the wind blowing today because I’d like to watch television, darling,” and of course the crowd went wild as he continued his tangential stand-up, impromptu riff.
by Dr Bunnygirl March 4, 2019
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Disappearing in the middle of a MacMillan cancer support Game Heroes stream to eat chicken for an hour.
Chris: Dave, where are you going?
Stenner: He's going off for a Crilly.
by SirN1Xy December 1, 2020
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choosing an option that wasn't presented, whether that be on an actual menu or in other phases of life
I'm tired of this same old food. I'm going off-menu with this one. I want a Big Mac, but with only BBQ sauce, Onions, Lettuce and cheese.

Known versions of going off-menu include, but are not limited to: the McChurger & the McOctogon
by Insidivs February 2, 2010
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Expression that can be used versatilely;

1) When one wants their pal to do great at whatever they are doing aka hyping them up
2) In a sarcastic matter: For example when they are snapping for no reason really.
1) A: Im going to get some work done today

B: go off sis!

2) Gabe: You know that's not really the right way to do it, THIS is how it actually works.

B: That is exactly what I just did Gabrielle, but go off sis.
by n e t t mhm October 2, 2018
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A sarcastic phrase you tell someone when they’re “snapping” or throwing a tantrum
Jack: Are you sure your shoes are tied correctly?
Mike: yes, i ties them myself.

Jack: they really don’t look like it.

Mike: Go off sis.
by Krith January 9, 2018
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