Abbreviated form of "Good luck with that shit." Usually said to someone trying to accomplish the impossible.
"My dream is to have sex with a supermodel."

"Glwts."
by woofrikinhaw May 3, 2007
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Good luck with that.

Can be used in texts and/or I.M
In a text:

Johnny: Oh crap, i have to write a 1000 word essay by third block!

Doe: GLWT, dude!
by yreva11 October 15, 2008
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Person A: Hey, I'm gonna go ask that girl out.
Person B: GLWT, dude.
by Khanada May 9, 2006
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GLWTS often refers to "good luck with the sale" when used on comments on sale sites like auto auctions etc.
On an auction for a VW camper van:
Veddy nice – nothing matches the logic and layout of these and later Vanagon campers….GLWTS!
by Tprov December 8, 2018
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Person 1: I'm going to leap over tall buildings with a single bound.
Person 2: glwt
by Ten Ton Tigger November 5, 2013
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Trump thinks Giuliani can help him in Mueller probe. #GLWT
by @modeOFdemus April 19, 2018
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