To have intercourse (sex) with a female sheep.
Billy Bob: Hey Bubba, I have no date for the hay ride this Friday so I don't think I am going.

Bubba: Well Fuck Ewe then!
by Billy BullSchitter April 21, 2016
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A female sheep, the name “Ewe” (a noun) is generally used to indicate a mature female sheep and fuck (used as a verb) to indicate sexual intercourse.
Bobby: “I have no date for this weekend and I really need to fuck a girl”.

Bubba: “Well fuck ewe then, the barn is full of a bunch of new female sheep.”
by Billy BullSchitter August 1, 2016
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