This term seems to have originated from the 1984 film, "Ghostbusters." It was coined by Dr. Peter Venkman, played by Billy Murray, in reference to Dan Aykroyd's character.
"Wow, way to be on top of the decorating, Francine."
Person 2: Aw, I'm sorry, man!
Person 1: You're such a Francine.
Person 2: Okay?
Person 1: I *like* it.
freind: forget it, you have no chance with her
me: (after seeing her trip a couple of time) Oh yes, I think I do
Friend: yeah, if she keeps tripping like that definetey have a shot but don't Francine too hard!!