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3.
A clueless, nebbish, or otherwise lost individual. A Francine can be of either gender, and has nothing to do with femininity/masculinity. Rather, to be a Francine, one usually must make a dumb or glaringly obvious suggestion, or generally behave in a manner which is more becoming of a slightly brain-damaged garden slug.

This term seems to have originated from the 1984 film, "Ghostbusters." It was coined by Dr. Peter Venkman, played by Billy Murray, in reference to Dan Aykroyd's character.
"I was thinking that maybe for Halloween, we should carve some pumpkins!"
"Wow, way to be on top of the decorating, Francine."
by LightBoy January 25, 2006
 
1.
Someone that is amazing beyond all comparison. They are typically one of the best friends that you could ask for, always providing help in some way. The term probably originates from somewhere within the northern regions of Earth, but nobody is sure about it's first use.
Person 1: ...and then we ended up splitting.
Person 2: Aw, I'm sorry, man!
Person 1: You're such a Francine.
Person 2: Okay?
Person 1: I *like* it.
by It all adds up May 20, 2009
 
2.
Francine is a very old name that originates from France but is a latin word, it means beautiful flower. Usually Francine's are very pretty brunettes, with an average height and gorgeous intense eyes that speaks volumes of how they feel. They are beautiful but have a kind of awkwardness about them and an easy going nature that makes them approachable. The Francine's complains a lot but they do it in such a way that it's dramatic and funny. They make great friend and never let off their friendships but end up losing friends due their frank sometimes thoughtless remarks.
me: Hey, check out that classy babe,
freind: forget it, you have no chance with her
me: (after seeing her trip a couple of time) Oh yes, I think I do

Friend: yeah, if she keeps tripping like that definetey have a shot but don't Francine too hard!!
by Tomjkon February 05, 2010