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Definitely. From snoopified "for sure". Often used in preceding "my nizzle" as in "for sure, brother".
Q: "Wanna hit dis?"
A: "Fo shizle, my nizzle. Light it up!"
fo shizle by Anonymous April 2, 2003

Fo' Sholene 

A hit rap duo consisting of Jolene and Shannon. Their new album, Shock Me, is set to released on 4/20.

Songs include hits, "Jo gon give it to ya," which held the #1 spot on the charts for over 8 weeks. They also included their lateset hit, "Wake me up before you go get mashed potatoes."

They are best known for posing back to back doing the shocker symbol.
Fo' Sholene's lyrics pop my cherry.

First we gonna shock
Then we gonna shock
Then we let it pop
Don't let it go

JO gon give it to ya
She gon give it to ya
Fo' Sholene by Shannon Wojo April 9, 2008

Fo Shozzle 

A synonym for Fo Shizzle; For sure; Slang for agreeing with something or someone
FO SHOZZLE!
absolutely,positively and without a doubt
"Are there hooker's on figueroa?"
fo shizle my nizzle.
fo shizle by darktooth211 February 11, 2003

Fo' Shizle 

(or "Fo' Sho") For sure
"Iz u crunk?" "Fo' Sho!" -or- Fo' Shizle my Nizle
Fo' Shizle by gangstah September 14, 2006
gangsta1;yo gangsta wanna fuck my mom at the used car lot
Gangsta2; fo shizle dizle that would be off the hizle my nizle
fo shizle by nigga November 9, 2003