Dude to other dude:You aren't fluffeh enough to touch my fluffeh lizard, Fluffeh!
euphemism for a chubby person. not a morbidly obese person but a person who is generally more voluminous than the expected norm. for women it also means curvy or voluptuous.
tom: that fat girl in accounting just told me to bug off.
steve: she isn't fat, she's fluffeh.