It's 75% of the time annoying gameplay consists of running in fucked up zig zags across the Mojave Wasteland completing idiotic quests for 1 of the 3 more powerful groups of people, which results in the other two hating you for no reason. The limit for inventory items is 200, and what Bestheda didn't realize is that it takes more than 200 items to survive 2 seconds without being attacked by a group of unrealistically large scorpions when going to an undiscovered area.
This difficulty causes the player to take everything in their path, which will then cause the player to not only become "overencumbered" with in-game objects, but the several stupid quests that pop up when you're trying to complete just one.
Fallout: New Vegas is so annoying that it provokes the player to keep playing until they've finished it. However, it is actually quite a good game.
Player 2: Okay, I'll Play After This Quest.
5 QUESTS LATER
Player 1: Are You Gonna Play GTA?
Player 2: I'm Playing Fallout: New Vegas. I'll Play After This Quest.
Guy: "Yeah I'm kinda busy wandering the Mojave Wasteland on Fallout: New Vegas."
Person B: lolwut?
Person A: Fallout: New Vegas
Person B: Oh yeah... Fallout 3 will still be better tho'
Person A: lol how can you know?
Person B: because Obsidian is making it
Person A: lol stfu
Person B: gtfo and bbq
Person A: hdf
Person B: what?
Person A: german abbreviation for STFU
Person B: >_>
Jack:Hang on, I'm killing Centaurs, Super Mutants, and Legionaries on Fallout: New Vegas.
Jack's Girlfriend: We're through!
Jack: That's fine, I've been cheating on you the whole time.
Jack's Girlfiriend: With who?
Jack: The Mojave Wasteland.