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Simply, FTFO means "Fight the Fuck On." It's a play off the Trojan phrase "Fight On," but gives it more of a kick (even though Trojans always go hard, it's just assumed they all Fight the Fuck On.)
We beat the bRuins 50-0! FTFO!
by TrojanForLife January 29, 2012
Freaked the Fuck out; Could also mean Freak the Fuck out.
It's just Salvia, don't FTFO.
by Orpheus9000 May 26, 2010
Album by Shaggy 2 Dope; FTFO AKA Fuck the fuck off.
Juggaho: Your taste in music sucks.
Juggalo: FTFO!
by SakuraChan June 28, 2007
Flip The Fuck Out. Describes someone losing their cool, going apeshit, out of control.
The boyfriend F.T.F.O. after catching his girl in bed with another girl.
by JazzyJuggs November 13, 2006
Abbreviation for Flip the Fuck Out
Dude, that little kid next door was so annoying... I was about to FTFO
by Jamgasm675 August 02, 2008
fly the fuck out
let me get that blunt im about to Ftfo of this bitch.
by letsftfo July 18, 2010
1. An abreviation for FTFO
2. A CD by Shaggy 2 Dope from ICP
"This shit ain't for pussy heads (So fuck off)
This ain't for you rookie kids (FTFO)
Bloody creatures carve your head out (So fuck off)
This the shit that brings the dead out (FTFO)"
-Shaggy 2 Dope
by Selice August 29, 2006