Top Definition
FTDOTU was coined by the famous Dan and Br2tt of Pokemon Paradise. It stands for For The Domination Of The Universe, as an extreme adjective, rather than just plain old FTW. It should only be used when describing something immensely awesome. Fail use of the anagram will not be tolerated. Will result in an extreme ass kicking.
No man, it's ftdotu.
by NaughtyNatasha June 14, 2010

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