When your profile picture doesn't look like you, but it looks worse than what you look like in real life. (Can also apply to myspace, but particularly facebook)
Guy:Have you seen my profile pic???
Girl:OMG its horrible. You have a serious case of Facebook Disease (FBD). You look way better in person.
Guy: Oh really? Thanks.
Girl:OMG its horrible. You have a serious case of Facebook Disease (FBD). You look way better in person.
Guy: Oh really? Thanks.
by Dough.Boy. June 15, 2008
When you're on Facebook and see your friends looking like they're living amazing lives while you're feeling like you're just barely making it and you become sadder and sadder with each update you see.
Person 1- Dude! every time I'm on Facebook everyone seems to be having these awesome ventures while I'm here sitting around! I feel like ****!
Person 2- Looks like you've got a serious case of Facebook Depression Syndrome (FBDS) going there, bruh.
Person 2- Looks like you've got a serious case of Facebook Depression Syndrome (FBDS) going there, bruh.
by TheDavid02 June 4, 2011