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down’s syndrome 

some of the most amazing people on the planet who are actually extremely intelligent (coz sum of y’all clearly aren’t, throwing shade) and hilarious and beautiful and wonderful human beings. take it from me my sister has it. no it’s not a fucking disease, nothing reduces or amplifies it, you can’t catch it (wtf), people with it don’t suffer, and they’re something funny cute and awesome! so for all y’all insulting people by calling them down’s syndrome, a) find a better insult, b) get a fucking life, c) google it before you use it to be mean and d) think about how other people who know people with down’s syndrome actually feel about you using language like that?!
see that girl over there, she has down’s syndrome, look how happy she is. she looks like so much fun
down’s syndrome by belladanke November 13, 2018

down's syndrome 

Even god finds them funny.
Down's syndrome kid: "Help me, my eyes are r8 small but ma head's pure massive"
Guy watching: "Hahaha oh my god you should be put down."
down's syndrome by sdw298 May 5, 2008

Amber Down’s syndrome 

A very rare serious disease that shouldn’t be taken lightly. Symptoms include;
- shitting yourself
- kidnapping people’s pets
- constant Facebook live sessions

- masterbating with pliers

- stealing peoples boyfriends/ex’s
- feeding pets bath bombs
“Shit I’ve caught something I’ve been to the doctors and they’ve diagnosed me with Amber Down’s syndrome it’s incurable”

Internet's Down Syndrome 

A temporary condition brought on by the lack of internet connectivity and characterized by irritability, fidgeting, lack of focus, a general feeling of helplessness and occasionally exercise.
Steve: What's up with the glazed look on Meredith's face?

Brad: Well, she likes to start her day reading Perez but we have no connectivity and slipped into an acute case of Internet's Down Syndrome.

down's symdrome 

down's symdrome:A condition resulting from a chromosomal abnormality characterized by mental retardation and such physical signs as slanted eyes, flattened facial features, short status and tendency toward obesity. this is down's symdrome .
you are a fuckin' mongo!
you got down's symdrome or summit?
down's symdrome by nikki101 June 23, 2006

Downey Syndrome

A condition caused by living, or being raised, in Downey, CA. Sufferers who grew up in Downey and have since moved away will experience profound feelings of unsubstantiated nostalgia about their childhood home and may suffer from the delusion that Downey is a great place to live; while the afflicted who currently reside in Downey will display extreme frustration, confusion and despair, interspersed with periods of complete denial ("I'm probably going to move to Orange County next year.") Those who grew up in Downey and still live there are the most severely affected as they continually battle conflicting feelings of sentimentality and condemnation.

Symptoms include: a tendency to inadvertently blurt, "Go Bears!" or "Go Ducks!" (depending on whether they attended, Warren High School or Downey High School) whenever the word Downey is used, regardless of the context ("Did you want to go see the new Robert Downey, Jr. movie?" "Go Bears!" "No, Iron Man."); an inability to control the impulse to compare all foods to that served at El Taco; an inexplicable need to mention that Karen Carpenter was also from Downey (followed by deep shame at their lack of control and anxiety that people will assume they like The Carpenters) and feelings of superiority over those who reside in Bell Gardens, Pico Rivera, Paramount and Lynwood based on the misperception that Downey is somehow less ghetto.
Bob: So you're from Paramount?
Jack: Hell no! Do I look like I'm from Paramount? I'm from Downey!
Bob: What? Like somehow being from Downey is better than . . .
Lori: Shhhhhhhh . . . he can't help it. He has Downey Syndrome.
Bob: Oh. Sorry big guy. Go Bears!
Jack: (clapping hands and laughing) Yay!