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1.
Double Helix is the situation, commonly referred to as a game, in which two semi-erect men twist their dicks together to form what resembles a DNA Double Helix hence the name "Double Helix."
Greg: Hey John, wanna play double helix?
John: Let's do that! Let's do exactly that!

<game of tummy sticks ensues>

John: Shit! I hate it when I get my Schartz twisted.
by DoubleHelixGame October 16, 2010
 
2.
The extremely intoxicating effect of smoking marijuana after drinking too much alcohol. It is not the same as smoking before drinking. To those not used to it's effect experience vomiting and abject fear.
Last night Joe got the Double Helix and puked all over my girlfriend.
by Johnnie The Hat January 08, 2009
 
3.
A duo of guys in England that are mostly known for helping The Super Flash Bros. The members of Double Helix are: the founder, JT, and Dan.

The group was created when they participated in a Newgrounds Flash collab, "The Matrix Has You" (the name isn't in the list, but they still participated). After that, they started helping The Super Flash Bros with the Decline of Video Gaming series.
Double Helix... Decline of Video Gaming 1/2/3... ho hum.
by Joshua Squires October 05, 2005
 
4.
dou·ble he·lix
noun
noun: double helix; plural noun: double helices
a pair of parallel helices intertwined about a common axis, especially that in the structure of the DNA molecule.
Double Helix, A pair of parallel helices
by Research Triangle High School October 22, 2014