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1.
D4M
Short for "devastating for morale". Used to describe excessively painful/uncomfortable events.
Husband: "OMG, we lost all our money in the stock market."
Wife: "Wow, thats really D4M

Arash: Wow you just beat me four times in a row.
Jonny: D4M isnt it?
by Jonny Iosim February 22, 2009
 
2.
D4M
Down for me. Used meaning that the subject wants to 'get with' you. Can be used sarcastically or honestly.
Ex 1:
Beth: That guy Daniel talks to you all the time.

Fran: Yeah i think he be D4M.

Ex 2:
Fabio: Glinda, I think you're stupid and mean.

Glinda: Whatever dude, you know you're D4M.
by lowlowlowlowlowlow January 22, 2010