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1.
Extreme dry mouth that follows smoking marijuana.
"That blunt just gave me the worst cotton chops I have had in a while, we need to get some water"
by old man withers August 16, 2006
 
2.
When after smoking large amounts of pot your mouth becomes dry and pasty.
Dat dooby gave my ass some serious cotton chops.
by JustR December 31, 2009