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1.
A combination of things. Usually in a hectic and chaotic manner, but connected enough to make sense. Similar to concoction, but with less measuring. Like Jumble, but with more cohesion. Usually each part of a combobulation is different and ridiculous enough to require a use of the word "combobulation".

Should always be used in the manner of: _____ is a combobulation of _____, _____, and _____.

Never: i combobulated _____ out of _____, _____, and _____.
What the hell, this food is like a combobulation of feces, stognaoff, and crackers.
by ReZeroX April 10, 2006
 
2.
combination of a whole lot of messed up shit.
Cassie is hot
by Sarah January 20, 2004
 
3.
addition of any two or more numbers
what is the combobulation of 4 and 7...11
by Bridg-ee October 12, 2006