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1.
Doing lines or bumps of coke and ketamine at the same time
user1: Who wants to Calvin Klein?!
user2: I do, I do!!!
user3: You betta werk bitch! CK'ing is fierce!!
by CA dream'in August 02, 2006
 
2.
A drug slang term used to describe a cociane and ketamine combination. The term originated from the new york dance scene back in the day.
They got super messed up on a calvin klein combo.
by D.Rock December 28, 2006
 
3.
When you try to pull someone and they turn you down (aka decline you).
Guy 1: hey man, i tried it on with that smoking bridesmade last night

Guy 2: Ha nice, howd it go?

Guy 1: Yeh she Calvin Klein'd me straight up - embarrassing
by cj12 May 29, 2010