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1.
A reference to the movie "Ferris Bueller's Day Off"

Used as filler when nobody responds to a question or statement.
Person 1: Has anybody seen my hat?
Person 2: ...
Person 1: Bueller?
by Nathaniel Jones June 07, 2005
 
2.
someone, usually a friend that misses out on class ocasionally.
person 1: hey, why werent you in class today?

person 2: i didnt feel like waking up.

person 1: wow bueller, come to class next time.
by dman1008 November 16, 2009
 
3.
From the title character in the classic movie "Ferris Bueller's Day Off".

To take time off work, in an unauthorised and if possible un-noticed way.

Most commonly to leave work for lunch with a few close friends and not come back.
Slacker1: How's it going?
Slacker2: Man. I pulled a bueller yesterday afternoon and my boss didn't even notice!
Slaker1: Excellent.
Slacker2: Yeah.
by Martin C. November 10, 2003