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1.
A nickname for William Shakespeare, which is way to long to say in casual conversation.
Felix: Did you read the Billy Shakes assignment for English last night?

Cornelius: Yeah, I liked the part where everyone died at the end.
by Wile E. Ferret June 24, 2005
 
2.
Stage name sometimes used by Shaved Hamster singer Stewart Jennings. Shaved Hamster is an Indie Rock band based out of South Florida.
Billy shakes rocked the twat out of that mug biatch!
by hamsterhead June 16, 2010