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2.
Usually relates to the "Big Four" Grunge bands of the early '90s.
The Big Four are:

Soundgarden
Pearl Jam
Alice in Chains
Nirvana

Even more interesting, they all come from Seattle
"The Big Four were pioneers for the Grunge genre, not to mention, they just plain kick ass!"
by GrrTigerMonster April 07, 2009
 
1.
The REAL Big four, unlike someones definition, are the kings of thrash metal.
The big four are:
Metallica
Megadeth
Anthrax
Slayer
In that order
by EIEKTRICEYE September 17, 2011