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2.
To 'Base Up' refers to one of three things.

1. The application of hand sanitizer (from the base to the tip, hence the name) to ones genitals before or after a particularly questionable bout of intercourse (though a post-coital 'base up' is less likely to result in unwelcome friction).

2. In reference to the sexual encounter itself, whereby you engage in risky business and will likely require the application of 'Base Up' in the near future.

3. As a noun referring to the sanitiser itself.
"I didn't use a condom, better base up"
"Should we base up before going to the clubs?"
"Who used all the base up?"
by Power Wine January 01, 2012
 
1.
When two bros are stationed at separate military bases, but are attempting to get stationed together.
Dude, when we base-up we'll get into all sorts of shit together.

I'm telling you, we're gonna rip it up as a wingman duo.
by D audi February 05, 2012