To make a sequel of something (ex. Games, shows, etc) and somehow fuck the source material up of unfortunately great proportions. The name is derived from the Anime Dragon Ball GT, which was supposed to be (If I recall correctly) a Non-cannon sequel to Dragon Ball Z. But when it released, it gained a heavy negative reception.
Guy 1: "I just watched Season 2 of The Promised Neverland, and it's bad."

Guy 2: "I agree, that Dragon Ball GT Syndrome that invaded the Anime sucks."
by NepgearAfficionado October 2, 2022
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When someone needs to feel bigger and more powerful than others.
OMG Paul is always trying to be little me to make himself better! He must have "big ball syndrome".
by Real_Man_12 March 6, 2018
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A syndrome occurring to a man who does not sun his balls. Most typically known as a: soyboy, little bitch, high estrogen levels, a loser
Miami guy1: Did you see Billy Corben crying again on Twitter?

Miami guy2: Bro, did I. That’s every day, that guy has major pale ball syndrome
by WJHTS August 9, 2022
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When a man believes that he is in complete control of his child or children along with their mother. He will continue this belief rather he is in a relationship with the child’s mother or not. Often using the child for their own gain. A female version of this syndrome would be Golden Uterus Syndrome.
Golden ball syndrome: “I can do whatever I want regardless of any opinion or court order”
by Island_Girl98 January 30, 2022
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