A game by Fantasy Flight which brings nearly every Lovecraftian entity into the small town of Arkham. About as close to DnD as you can get without playing DnD. It circulates around 1-8 players versus a myraid of monsters until the Great Old One appears, ranging from Azathoth to Yig.
"Hey, after this we can go to my place and play some Arkham Horror."
"Ok, but lets not fight Azathoth."