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1.
In real life or in a game such as the Juiced or Need For Speed series. When a car goes over the top of you whilst going over a ramp or when their is a sudden drop in the road. Also if you go over the top of another car during a jump.
John: Dude he just 2F2Fed me!
by Granty2k8 July 10, 2008
 
2.
Acronym for "2 Fast 2 Furious"
Used to describe drivers and car enthusiasts that base their opinions around the film "2 Fast 2 Furious". Typically used in an insulting manner.
Jawn: Dood I want a Aerial Atom so bad
Farris: man I just want to go under 18 wheelers with it
Jawn: thats so 2F2F
by Jawnasaurus Rex June 26, 2008
 
3.
"Too Fucked To Function"
2-F-2-F
tom: hey how was last night?
roy: man i passed out- i was way 2F2F
by GanjaGrrreen July 10, 2010