':S' Is used to express confusion. Often,it is directed towards someone else's stupid remark. For instance,if somebody is getting angry for an unneccessary reason. For general confusion,':s' is more likely to be used.

Or,':S' Is used when someone cannot explain their anger.

OR,it can be used by well-mannered people,at the end of an angry statement,to show that,although they are very angry indeed,they still have enough self control to make a smiley.

OR it can be used to lighten the mood at the end of an angry statement. So that the person who the anger is directed towards realises that the statement is not an invitation to argue.

i.e.

'I'm sorry, but you're post made me genuinely angry :S'

The person,by adding the ':S' is basically saying,'You've made me angry,but my anger is justifiable. I've made my point,so let's end it there. Don't bother arguing with me.'
Person 1. 'OMFG! I hate apples SO FREAKING MUCH!'
Person 2. 'It's just fruit...there's no need to get so angry :S'

Person 1. 'Did you know that The EXAMPLES kicked the lead singer out of the band,just because he was too fat?'
Person 2. 'OH MY GOD! Why the hell did they do that??? Oh my god! That's just ... grrr!'
Person 2. 'I thought you didn't even like The EXAMPLES? Why are you angry?'
Person 1. 'I don't know! I just..grrr! :S'

Person 1. 'I think all people with blonde hair are retarded.'
Person 2. 'That's a really stupid and nasty thing to say.'
Person 1. 'Not really...'
Person 2. 'Yes. It is. It makes me really angry when people say things like that :S'
by Bizaaaarre. April 19, 2010
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Stands for Albus Severus/Scropius. A shipping from the Harry Potter series taking place in the 3rd generation. The only known facts about this couple are sparse, but many people are taking advantage of this by continueing where H/D (Harry/Draco) 'left off'. This is a male/male pairing.
"The AS/S ship is a way to carry on D/H were it left off!"
"Hell yea!"
by Girpakistan August 25, 2007
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awkward face

for when things are awkward
when really awkward people are talking to each other about awkward things :s
by afdoherty November 21, 2010
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The nineteenth letter of the alphabet. After R and before T.
...rst...
by My name February 19, 2003
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\s is used to indicate sarcasm or satire. Inspired by HTML tags.
"I'm surprised to see a politician screw up like that. \s"
by imh January 11, 2012
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A smiley face that is confused or sick.
That!? What are you talking about S:

I'm feeling sick... S:, so i'll skip school today q:
by Linkzie June 29, 2006
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In the Harry Potter fandom, the pairing of Albus Severus Potter and Scorpius Malfoy. The two characters are featured only in the epilogue of Harry Potter and the Deathly Hallows; however, many slashers have already paired the two characters together.
as/s was the best thing that came out of the epilogue.
I'd tap that as/s.
by sushimustwrite July 23, 2007
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