n. The situation whereby a medical or medical/psychiatric condition causes a "domino effect" of other dangerous symptoms and conditions ensuing.

Named after the Rube Goldberg "contraption" machine, any machine that uses a chain reaction of events to achieve a final, trivial goal (in this particular case, possibly death).
After my brother had that bout with strep, it apparently got to his stomach and paralyzed it, giving him a nasty case of acid reflux, which in turn began to launch acid clear up into his throat and mouth, not only severely damaging his teeth... he's also he's worried he's going to get cancer one day from all that acid where it's not supposed to be. And to say nothing about all the dental surgeries he's gonna need... talk about a case of Rube Goldberg Syndrome!

(No really, it has happened.)
by Andy Khay January 23, 2009
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Taking a hit of a crack rock in an extreme manner.
"Hey Tony, did you see Shawn Kemp after his career was over? If you thought he could throw it down in the NBA you should see him slam dunkin rubes."
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Drunkenly setting a series of events in motion that ends in tragedy.
"How did the fire start?"
"Well, Mark was wasted and in reaching for his cell phone knocked over a glass, that fell on a power strip, that set the couch on fire"
"I see, classic Rube Goldberg Alcoholism"
by Bourbonsauce January 21, 2010
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Basically, a 'machine' that uses many ordinary items, and positions them in a way so that when activated, sometimes by 'knocking down the first domino' so to speak, it leads to a series of events that are all activated by the previous events.
They are most always elaborate, with many things going on at one time.
They are hard to build, and sometimes take over 4 months and a millions hours to build, but the results are spectacular.
Child 1: Hey, let's play Mouse Trap!
Child 2: I heard that's something called a Rube Goldberg Machine!

Teen 1: Have you seen Ok Go's new video, 'This Too Shall Pass'? It's totally a Rube Goldberg Machine!
by loveisjujujubaby March 14, 2010
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Applying mayonaise and jelly to the foreskin and or scrotum of a mans penis as lubrication for oral sex in preperation for a prostate exam
Scott Behm tryed RUBING MY SUBURBAN during our conversation on gay rights in the little boys section at K-mart.
by *suck my choad* August 15, 2008
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Being known as the worst person in a cube farm. Loud music and just being a pain to sit near in a cube farm.
This new dolt has made it to cube rube for being nothing but a problem in every respect in the cube farm.
by UD nut case August 7, 2009
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The act of creating something intentionally controversial so that you can claim that you're being unjustly censored when private businesses don't want to be associated with it, with the objective of motivating the easily-manipulated into reacting emotionally and patronizing/advocating for your product.

They willingly send you their money and encourage others to do the same as a protest of the legitimate market reaction to your creation.
"The Sound of Freedom" and "Try that in a small town" are some top-quality Rube-Bilking. They made a fortune off of those morons.
by TonyFromOuttaTown July 26, 2023
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