The listless state of consciousness experienced after eating a KFC Double Down sandwich.
Brad: "Why does Ken look like he's about to collapse?"

Trevor: "Judging by the lunch we just ate, it is my determination that Ken is suffering from Double Down Syndrome."
by Lamb Lamb April 17, 2010
Get the Double Down Syndrome mug.
A person who cannot get off fortnite. If they do they will crave it until they get back on. Some call it Fortnite down syndrome, others call it being 9 years old. What ever It is I have it.
Bro my little brother wont get off fortnite!
Yeah I saw, I think he has Fortnite down syndrome!
by WiiSports April 26, 2020
Get the Fortnite Down Syndrome mug.
A semi-uncommon disorder among Mexican immigrants, MDS consists of a total lack of knowledge of American culture and language. Phrases such as "Come over, i'll cook you", "I love the smell of burn", "Can I use powerful words?", and "Smelt" are used frequently. Patients diagnosed normally don't have many friends, and are give shit by nearly everyone.
Jay: Did Rosa just say,"Shit my hole"?

Matt: Give her a break, her doctor says she has a case of chronic Mexican Down Syndrome.

by Richard Pancreas February 22, 2009
Get the Mexican Down Syndrome mug.
aliens with down syndrome, that usually live in people's vagina's, preferrably mine
When I run, the down-syndrome aliens fall out of my vagina
by mapu March 30, 2008
Get the down-syndrome aliens mug.
1. An epidemic sweeping the nation causing puppys eyeballs to grow farther apart, thus allowing the brain to push forward in the vacant space, causing retardation.

2. Something to laugh at when at a party.
-Dude, why does your dog keep humping my leg?

-Oh Captain Foogles there has puppy downs syndrome.

-Hahaha.... Oh you're serious?

-It's an epidemic.
by Dr.Kunk November 3, 2009
Get the puppy downs syndrome mug.
Freddy Down syndrome -

A name for a boy name quinton who’s bitmoji looks like Freddy Kreuger . And he bullies gram for being named after a cracker when he’s a Down syndrome nacho taco chimmy chonga.
look it’s Freddy Down syndrome ! He prollys Down syndrome “
by Sneeeeeeeeddddddarritaaa October 21, 2022
Get the Freddy Down syndrome mug.