that ONE ugly, unpopular person in a group of popular, or hot people. (DUFF stands for designated ugly fat friend.)
by turtles.166 June 29, 2015

Duff (duff) v. To leave.
by Dan Tucker December 02, 2003

The leftover remnants of meth after smoking. Or small crystals of crappy meth that can be found on tables, etc, in a meth user's home.
We opened to basement door and told Jeff's uncle it was time to go. He screamed "Do you want me to do this F*kking Duff, or what!!!!??" while pounding a table.
by StinkyPP August 08, 2008

To duff. (v)
1) An unspecified act, with the ability to surface in the conversation with vague initialization; a general verb replacement, adding emphasis on the action done.
2) The action/s brought upon in the rare situation of a peg-leg and/or amputee impaling another person’s chest at high velocity, generally in the process of a high-altitude attack.
1) An unspecified act, with the ability to surface in the conversation with vague initialization; a general verb replacement, adding emphasis on the action done.
2) The action/s brought upon in the rare situation of a peg-leg and/or amputee impaling another person’s chest at high velocity, generally in the process of a high-altitude attack.
1) a. "Dude, I'm totally going to duff you in the face if you don't shut the fuck up."
b. "Oh yeah? Well I duffed your mom last night."
2) (In the context of 'Rules of Engagement')
"Yeah, I can totally see that little stubby girl duffing him in the chest."
b. "Oh yeah? Well I duffed your mom last night."
2) (In the context of 'Rules of Engagement')
"Yeah, I can totally see that little stubby girl duffing him in the chest."
by Jeff Ott July 23, 2008

by Tin973 November 10, 2006

"designated ugly friend"
an ugly poor girl you use to laugh at. She has such a scummy pathetic life and drives a 2 dollar pos. Her face is ugly too. Her family is fucked in the head and she makes you feel better about yourself. Though you don't have to, she can make anyone feel better about herself since her life is such a piece of shit.
an ugly poor girl you use to laugh at. She has such a scummy pathetic life and drives a 2 dollar pos. Her face is ugly too. Her family is fucked in the head and she makes you feel better about yourself. Though you don't have to, she can make anyone feel better about herself since her life is such a piece of shit.
Boyfriend: don't call the duff tonight, she's too psycho to hang out with.
Girl: Don't worry, i won't, i don't hang with her anymore, it ruins me reputation.
Girl: Don't worry, i won't, i don't hang with her anymore, it ruins me reputation.
by tawns02 December 09, 2008

She is up the duff
by Britboylangers May 21, 2004
