The old southern meaning of spoof or the act of "spoofing" is to trick or otherwise play a practical joke on someone. (This might be remembered from the old "Deputy Dawg" cartoon where the mischievous Muskie the Muskrat constantly spoofed Vince Van Gopher, Deputy Dawg and Sheriff.)

Muskie: "Depty Dawg, Depty Dawg! Vince fell in the quickmud!"
Deputy Dawg: "Dag nabit! This better not be a spoof, Muskie!"
Muskie: "It's possible... It's possible..."

by Nabru September 14, 2005
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The sexual act of shoving cocaine up someone's ass.
I heard that Father O' Brien got spoofed by the Pope.
by iitc August 28, 2018
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a parody of a TV show, historical event, video game, etc.
VideogameDC.com is all about spoofs on video games.
by Light Joker September 30, 2004
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Most commonly refers to a parody, less commonly refers to a meth pipe.
Did you see SNLs spoof of Sarah Palin? it was hilarious.

Me and my buddy bought a eightball, and we were hitting the spoof all night.
by Cruxwillow August 17, 2009
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A parody of sorts, it is usually making fun of something.
Dude, I saw this hilarious Naruto Spoof! XD
by onions_r_good July 11, 2008
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thereis alot of different meanings. the one i know abot is to cum
by klaja26 October 28, 2003
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Spoof, verb.

When smoking marijuana out of a bowl, homemade or otherwise, the act of exhaling forcefully (normally a cough) without removing your mouth from the apparatus and blowing the weed everywhere.
by dirksauce September 2, 2008
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