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1. in reference to how one twists the pickle while smoking meth
"How do i do this?"

"10 to 2 nigga, twist it!"
10 to 2 by SwitchBlade June 1, 2006

2 & the 10 

blue balls (i.e. the two blue balls in billiards)
I thought I was gonna stab but she sent me home with the 2 & the 10.
2 & the 10 by dipper5150 May 5, 2009
Noun - An ugly girl who gets better looking the more you drink.
See - Beer Goggles
See - Butterface
See - Local 12 Step Rejects
she was a 2 at 10(pm) but at "10" at 2(am)
2 at 10 by se7en 154 May 8, 2003
The last ten minutes before most of the clubs shut. This is when deperate lonely chumps get off their asses and hit the dance floor seeking easy prey for their sexual needs. During this short period it is not rare to see desperate males going beyond the "2 above - 2 below" points rule that is generally accepted.
Chump 1: "10 to 2 bois! Let's get some pussy on the go!"

Chump 2: "That bird is a 10 to 2 at best."
10 to 2 by Jandy May 6, 2008

2 girls 10 cups 

a ruit team name for the beer game that uses 10 cups. This team name alludes to the popular 2 girls 1 cup motto of cupchicks.com
Girl #1: We need a team name for the ruit tourney this weekend!
Girl #2: I was one this awesome website last night and i came up with the best idea!
Girl #1: OMG OMG, what is it???
Girl #2: 2 Girls 10 Cups
2 girls 10 cups by deeezalll January 28, 2009
She/He was a 10 at 2. This means the girl/guy you would have never talked to at the begining of the night has made it into your life by the time the bar closes at 2am. By rating her on a scale of 1-10 due to the alchol she/he has became a 10 at 2.
Guy 1: Hey man did you see that girl i hooked up with on saturday?

Guy2: Yeah man saw her at the begining of the night, She must have been a 10 at 2.

Guy1: Yeah lets just keep her a secret.
10 at 2 by zmoney12 May 1, 2009