The act of being in charge, to take control.
Did you see Bethany running shit the other day at work when Terri and Jess got into a fight?
by bkv2 April 5, 2013
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To be in a dominating position where one has total or a large share of control over an industry, business, enterprise or most often a drug spot.
1)

Chump: Yo look at that Escalade on 22s, that must be the cash money millionaires
Lil Nigga: Nah that's poppi, he runs shit down on 25th son

2)

"You think this is a joke motherfucker? I RUN shit, not you. The game is MINE! (shoots competition in the face)"
by wza August 6, 2005
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Thinking you're too cool; and you often have sex Cami Style.
Crushing an apple on your own head to intimidate an upper classman.

Ex: "Oh my god do you see Joey? He is totally running shit!"
by JoeyWarren123 January 2, 2012
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usually happens while walking around a mall, school, or house. starts with a walking fart, then quickly turns to the running shits. these are something not for the weak at stomach, however stomach flu can make them much worse. sometimes referred to as the trots, or explosive diarreah.
omg me and charles were walking around the mall the other day, he got the walking farts and then suddenly he had the running shits.
by sweetontweety7777 April 17, 2009
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when someone is shooting at you or your girlfriend has pms. either way your pretty much totally fucked.
guy with a gun, or your girl friend at one time of the month, as in oh shit! fucking run!
by Im totally hyper October 18, 2007
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When you shit on something near and dear to the heart of one of your enemies (such as their lawn, their porch, their kid (which is fucked up), their car… you get the point) and then run away before the cops tie you down and get a spinky sample in order to get your DNA for testing and figure out why you’re such a fucked up human being. Happens more often than one would expect.
Anthony Jizzo: Yo Miguel, how’s the baseball season going?

Miguel Cumbrera: Not too good Jizzo. I decided I’m going to retire and move on to my next adventure in life. I decided to take an Albert Pujols on Nelson Cruz’s $200K car, so now I gotta change my name and move to Mexico before the poolice figure out I did it and ruin my repootation. I am the king of shit & run.

Stoney: Damn Cumbrera Sombrero, I enjoyed watching you all these years. It won’t be the same without you my boy.

Miguel: Thanks J-Man, I just don’t have any cum left to give. My OPS is only .669 these days, so I’m gonna go out on top. Good luck with the rest of your season with the Yankees, you play a solid first base.
by Stoney69 August 18, 2022
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