The term OTP has many meanings, such as On The Piss (Drinking terms), Outside The Perimeter (Atlanta slang), One True Pairing (In Fandoms), and many other meanings.
On The Piss: "Man, we're gonna be OTP tonight!"
Outside The Perimeter: "Oh my god some she's sooo OTP!"
One True Pairing: "My OTP is John Egbert and Karkat Vantas, definitely! JohnKat forever!!!"
Apart from 'One True Paring',
OTP is New Zealand slang for 'On the piss '.
'Piss' can be slang for alcohol, so On the Piss means to be drinking alcohol (usually a lot) or used when someone is talking about drinking alcohol in the future.