A physical malformation resulting from the over-consumption of the popular party drug mef, or "mefamphetamine."
If you don't lay off the mef, you're gonna get da mef mouf.
by ericalexander June 28, 2011
Get the mef mouf mug.
When a methhead does something f'd up. (or messed up)

Meth-heads by nature have nil, or at best, limited teeth left.

Hence the pronunciation of "Meffed Up".

Can be used to describe a person's appearance, or an egregious situation, the term can be used quite broadly and still remain effective in meaning.
Did you see that lady back there... (grimaces/smirks) "Dude, she was all meffed up!!"
by NWH November 2, 2010
Get the Meffed Up mug.
a mixture off miffed and pissed off, so therefore annoyed
Duncan was meffed off that the girl he was in love with continued to refer to him as her GBF.
by duncan's gbf July 27, 2009
Get the meffed off mug.
The euphoric state one finds them self in after consuming copious amounts of methamphetamine with their Bestie.
Ali and his Freemasons must’ve hocked their holes at the traino because they’ve got the big bag and they are extremely fucking meffed
by Joogie joog August 26, 2022
Get the Meffed mug.
In other words (bed)
My dad just yelled at me, I have to go to mef.
by You.r.ove October 28, 2021
Get the Mef mug.