Similar to IBS,Irritable Friend Syndrome can occur when a friend unexpectantly morphs into an obnoxious bitch, but you have known them too long to severe the relationship.
Help me! I have serious IFS with my best friend since 7th grade and I don't know how to tell her to shut the hell up without hurting her feelings.
by Jeanniebean137 October 25, 2007
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My god, look at that fire crotch, and an IFS to boot!
by amotiser August 25, 2010
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Idiot Freaks. All of those people with no common sense who act as if they know what they are doing. Who try to communicate with others, ie you and me , in an attempt to feel normal and part of the human race. You may not know if you are an IF, but you have surely been affected by one or more in your lifetime.
Ifs try to turn left from the right hand lane without a signal and then flip off the person who they cut off.
Ifs push an empty stroller in Disneyland and there is no child in sight.
Ifs read this on a Friday night.
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Insufficient Funds Syndrome. Usually a diagnoses will be performed by your bank, instead of your doctor. Symptons include, but are not limited to; Having to put all your groceries back at the supermarket, Hearing the cashier say, "sorry sir, but you cannot purchase porn and cigarettes because your card has been declined.", And the most severe symptom is having no life, no friends and definitely no girlfriend. Not all people with IFS experience these symptoms, but do not be fooled, this syndrome is not one you would like to contract.
"Dude, I went to the bank earlier and they told me I have IFS, how do I tell my girlfriend?"

"I'm afraid I can't #crackacoldonewiththeboys tonight bro, I have IFS."
"I really want a fidget spinner, but with IFS, my choices are limited to watching videos on YouTube about 11 year old kids who are already fidget spinning pros, when I know that I would be the best in the world if I just didn't suffer from IFS."
by Kaper_215 June 26, 2017
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Usually originates from a Blindian heritage. Found to pay upmost respect to people of a Chindian culture. They tend to be wild and found slizzard.
They are so ife
by continental1 January 3, 2011
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In Fucking Economy. This is an expression of dismay when a person fails to achieve a one-class upgrade on a very, very long flight.
OMG, IFE from Tokyo to San Francisco. FML.
by FlyR June 25, 2010
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Internet Faggotry Syndrome, or IFS for short, is where a seemingly normal human being IRL becomes a total faggot online. They transform themselves entirely, much as Optimus Prime does.
Person with IFS:

IRL: Hey man let's go back to my place and watch the game, I hope the (local team name here) win!

On the web: lol! do u want to come over n watch the game? lmao its gona b such a kewl game! lol
by habs.fan January 20, 2008
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