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twitter tweaker 

A user of a social networking site who tweets about being strung out on meth.
That twitter tweaker had a status update at 3:45 am she better put the pipe down.
twitter tweaker by BigJohnMich March 7, 2010

Tinkle Tweaker

Tinkle Tweakers are meth users who store their urine and feces, and attempt to recover the un metabolized methamphetamine from the urine and feces when they get desperate for another high.
The police broke down the door of the meth house only to discover the users were paranoid "Tinkle Tweaker s" and had jars, bottles, buckets, pots and pans full of urine and feces in case they desired to get high again and didn't have enough meth on hand.

lerping tweaker 

Acting sketch as fuck in bushes with binoculars during the day creeping on people or going on tweaker missions.
Scott H. was being a lerping tweaker going through Jens stuff while she was sleeping

secret tweaker pad 

1) The name of a song by the infamous So-Cal band, Sublime
2) A pad/house/apartment/dwelling in which methamphetamine is abused for days on end.
3) A pad/house/apartment/dwelling where methamphetamin is manufactured for personal use. The methamphetamine labs sometimes explode because the maker is tweaking so bad on meth while he makes more meth.
4) A secret dwelling where drugs are widley abused and endless partying ensues
1 - STP is my favorite sublime song ever!!!
2 - Hey man, lets go to that secret tweaker pad and get tweaked
3 - Billy doesnt want to come chill with us for the next week or two because hes at his STP... Maybe he'll die soon/
4 - Lets go to that secret tweaker pad and get shitty!

Gas Station Tweaker 

Someone who tokes up on "Gas Station Lush" and gets the wrong kind of "High."
Ian: "I KNOW YOU'VE BEEN SMOKING THAT SHIT ANTWON. YOU A GAS STATION TWEAKER!"

knob tweaker 

A synth user who obtains a wide array of sounds via tweaking or editing synthesizer sounds or patches to achieve a desired sound.
Bob is a knob tweaker, he's one of those dudes you see in a coffee shop twisting the knobs on a synth to make atmospheric music.