When a chick, who is usually fat, gets skinny, then fat than skinny again. But she always ends up fat for a while, suffering from not being able to stay skinny. Named for Oprah's constant wait loss and eventaul regain.
Ted: That cow Hillary is fat again! She was skinny last week!
Pat: Poor bitch has Oprah Winfrey's Disease! She can't keep the wait off.
Pat: Poor bitch has Oprah Winfrey's Disease! She can't keep the wait off.
by APT October 13, 2005
by Bapty August 11, 2009
by WITTYMOFO December 4, 2013
If you disclose anything bad about your life, a person with Oprah Winfrey Syndrome will say they had it happen to them too. One day a guest on the Oprah show disclosed being sexually molested Oprah disclosed that it had happened to her too. Another day a guest disclosed using Cocaine, and Oprah said she did too. I'm not saying that Oprah and other's with this condition are lying, but they always seem to have a story of hardship that is equal, if not worse, than the one you just told.
here is an example of the Oprah Winfrey Syndrome
Suzy: I don't know what I'm going to do I just lost my job.
Pam: Girl, I just lost my job too, and I found out I'm not eligible for unemployment!
Suzy: I don't know what I'm going to do I just lost my job.
Pam: Girl, I just lost my job too, and I found out I'm not eligible for unemployment!
by FLINGSHOT September 20, 2013
a way to say that's another story entirely; similar to can of worms; back in the day when the oprah show was all shock television one day it would be cheating husbands the next it'd be drug-addicted prostitutes
Y: Our boss is such a dumbster!
X: Did you hear about him asking out the new secretary???
Y: Yes...don't get me started!!! That's a whole other Oprah.
X: Did you hear about him asking out the new secretary???
Y: Yes...don't get me started!!! That's a whole other Oprah.
by absolutely July 26, 2007
by carrie jackson March 25, 2018