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Uptown Gunk 

When you go up in the town and accidentally jizz when you see an extremely hot girl
Guy 1: *Sees really hot girls*
Guy 2: (Guy 1) DAMN LOOK AT THOSE REALLY HOT GIRLS!
Guy 1: SHIT UPTOWN GUNK
Uptown Gunk by GunkerDunker March 5, 2015

Uptown fuck 

Sex with a posh person
Person 1. That guy is such a rah, not sure I want to sleep with him.

Person 2. Why not? Everyone knows uptown fuck gon give it to ya

uptown real estate 

big boobs, area that is nice and safe in contrast to the grime and filth located downtown where a number of unknown diseases flourish
howard: i ain't ever eat pussy in my life but i wouldn't mind going downtown on that broad, she classy
desmond: real talk...she got some nice uptown real estate too, look like million dollar mansions
uptown real estate by bobbycuzin September 3, 2007

uptown funk 

The putrid odor resulting from the combination of feces, vomit, and alcohol that is the result of a hard night of partying in an uptown bar district.
After he was released from the hospital, Robbie threw away his clothing and took a 45 minute shower to remove the smell of the uptown funk from last night's bachelor party.
uptown funk by The Angry Ogre February 13, 2015

Uptown Mirdif 

Located in dubai, it is an area that was meant to be for families and friends to chill in coffee shops, restaurants, and do some light shopping. In reality though, it is a place where chammaks thrive, and the word uptown has become synonymous with the word chammak; dokha is smoked there, alcohol is drank in the park “secretly”, glue is huffed from mountain dew bottles, EC is huffed from old T-Shirts, and chammaks use this place as a meeting spot, hangout spot, and of course, and fighting ring. The security doesn’t do shit and only chases you for riding a bike inside; but they don’t give a shit if you kill someone so that’s why chammaks love it.
Chammak 1: Hey bro are you going to the blackout party tonight?

Chammak 2: Yeah man let’s go together though, you wanna take a cab together?

Chammak 1: Hell yea yabbi, let’s meet at the uptown mirdif taxi line and take a cab and run away from paying the fare when we get to jumeira.

Chammak 2: You read my mind yakhi.
Adjective. Literally referring to the high class area of town, Uptown can generally be used as a positive adjective in any situation.
"these shoes are uptown"
"this beer is uptown"

or...

Rob: "hey Cott did you get some poon-tang last night?"
Scott: "Why indeed I did kind sir! It was motherfucking UP-Town!"
uptown by Rob January 12, 2005